Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche

Adipose tissue (AT) has previously been identified as an extra-medullary reservoir for normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we show a subpopulation of leukemic stem cells (LSCs) can utilize gonadal adipose tissue (GAT) as a niche to support their metabolism...

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Pubblicato in:Cell Stem Cell
Autori principali: Ye, Haobin, Adane, Biniam, Khan, Nabilah, Sullivan, Timothy, Minhajuddin, Mohammad, Gasparetto, Maura, Stevens, Brett, Pei, Shanshan, Balys, Marlene, Ashton, John M., Klemm, Dwight J., Woolthuis, Carolien M., Stranahan, Alec W., Park, Christopher Y., Jordan, Craig T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938766/
https://ncbi.nlm.nih.gov/pubmed/27374788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.06.001
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