UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans

Notch-type signaling mediates cell−cell interactions important for animal development. In humans, reduced or inappropriate Notch signaling activity is associated with various developmental defects and disease states, including cancers. Caenorhabditis elegans expresses two Notch-type receptors, GLP-1...

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Vydáno v:G3 (Bethesda)
Hlavní autoři: Safdar, Komal, Gu, Anniya, Xu, Xia, Au, Vinci, Taylor, Jon, Flibotte, Stephane, Moerman, Donald G., Maine, Eleanor M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2016
Témata:
Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938665/
https://ncbi.nlm.nih.gov/pubmed/27185398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.116.027805
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