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Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction
X-ray crystallography has shown that an antibody paratope typically binds 15–22 amino acids (aa) of an epitope, of which 2–5 randomly distributed amino acids contribute most of the binding energy. In contrast, researchers typically choose for B-cell epitope mapping short peptide antigens in antibody...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4938180/ https://ncbi.nlm.nih.gov/pubmed/27189949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729020 |
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