Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2

Exocytotic secretion of digestive enzymes from pancreatic acinar cells is elicited by physiological cytosolic Ca(2+) signals, occurring as repetitive short-lasting spikes largely confined to the secretory granule region, that stimulate mitochondrial adenosine triphosphate (ATP) production. By contra...

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Bibliographic Details
Published in:Philos Trans R Soc Lond B Biol Sci
Main Authors: Peng, Shuang, Gerasimenko, Julia V., Tsugorka, Tatiana, Gryshchenko, Oleksiy, Samarasinghe, Sujith, Petersen, Ole H., Gerasimenko, Oleg V.
Format: Artigo
Language:Inglês
Published: The Royal Society 2016
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938023/
https://ncbi.nlm.nih.gov/pubmed/27377732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2015.0423
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