Caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury is mediated via RhoA and ROCK activation in major pelvic ganglion

Axonal injury due to prostatectomy leads to Wallerian degeneration of the cavernous nerve (CN) and erectile dysfunction (ED). Return of potency is dependent on axonal regeneration and reinnervation of the penis. Following CN injury (CNI), RhoA and Rho-associated protein kinase (ROCK) increase in pen...

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Publicado en:Sci Rep
Autores principales: Hannan, Johanna L., Matsui, Hotaka, Sopko, Nikolai A., Liu, Xiaopu, Weyne, Emmanuel, Albersen, Maarten, Watson, Joseph W., Hoke, Ahmet, Burnett, Arthur L., Bivalacqua, Trinity J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937405/
https://ncbi.nlm.nih.gov/pubmed/27388816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29416
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