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The human PMR1 endonuclease stimulates cell motility by down regulating miR-200 family microRNAs

The motility of MCF-7 cells increases following expression of a human PMR1 transgene and the current study sought to identify the molecular basis for this phenotypic change. Ensemble and single cell analyses show increased motility is dependent on the endonuclease activity of hPMR1, and cells expres...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Gu, Shan-Qing, Gallego-Perez, Daniel, McClory, Sean P., Shi, Junfeng, Han, Joonhee, Lee, L. James, Schoenberg, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937341/
https://ncbi.nlm.nih.gov/pubmed/27257068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw497
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