ASAFE: ancestry-specific allele frequency estimation

Summary: In a genome-wide association study (GWAS) of an admixed population, such as Hispanic Americans, ancestry-specific allele frequencies can inform the design of a replication GWAS. We derive an EM algorithm to estimate ancestry-specific allele frequencies for a bi-allelic marker given genotype...

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Publié dans:Bioinformatics
Auteurs principaux: Zhang, Qian S., Browning, Brian L., Browning, Sharon R.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937201/
https://ncbi.nlm.nih.gov/pubmed/27153656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btw220
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