GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition

BACKGROUND: The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin 1 (mTORC1) signaling pathway is aberrantly activated in renal cell carcinoma (RCC). We previously demonstrated glycogen synthase kinase-3β (GSK-3β) positively regulated RCC proliferation. The aim of this study was to...

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Bibliografische gegevens
Gepubliceerd in:BMC Cancer
Hoofdauteurs: Ito, Hiromi, Ichiyanagi, Osamu, Naito, Sei, Bilim, Vladimir N., Tomita, Yoshihiko, Kato, Tomoyuki, Nagaoka, Akira, Tsuchiya, Norihiko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936323/
https://ncbi.nlm.nih.gov/pubmed/27387559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2418-7
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