Early postnatal GABA(A) receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1

Exploring drug targets based on disease-associated molecular mechanisms during development is crucial for the generation of novel prevention and treatment strategies for neurodevelopmental psychiatric conditions. We report that prefrontal cortex-specific postnatal knockdown of DISC1 via in utero ele...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Psychiatry
Main Authors: Saito, Atsushi, Taniguchi, Yu, Rannals, Matthew D., Merfeld, Emily B., Ballinger, Michael D., Koga, Minori, Ohtani, Yoshikazu, Gurley, David A., Sedlak, Thomas W., Cross, Alan, Moss, Stephen J., Brandon, Nicholas J., Maher, Brady J., Kamiya, Atsushi
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935661/
https://ncbi.nlm.nih.gov/pubmed/26728564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.203
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