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Interactions between Anandamide & Corticotropin-Releasing Hormone Signaling Modulate Human Amygdala Function & Risk for Anxiety Disorders: An Imaging Genetics Strategy for Modeling Molecular Interactions

BACKGROUND: Preclinical models reveal that stress-induced amygdala activity and impairment in fear extinction reflects reductions in anandamide driven by corticotropin-releasing hormone receptor type 1 (CRHR1) potentiation of the anandamide catabolic enzyme fatty acid amide hydrolase (FAAH). METHODS...

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Bibliografische gegevens
Gepubliceerd in:Biol Psychiatry
Hoofdauteurs: Demers, Catherine H., Conley, Emily Drabant, Bogdan, Ryan, Hariri, Ahmad R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935637/
https://ncbi.nlm.nih.gov/pubmed/26923505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2015.12.021
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