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General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice
Treatment with the antileukemic agent asparaginase can induce acute pancreatitis, but the pathophysiology remains obscure. In the liver of mice, eukaryotic initiation factor 2 (eIF2) kinase general control nonderepressible 2 (GCN2) is essential for mitigating metabolic stress caused by asparaginase....
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| Udgivet i: | Am J Physiol Gastrointest Liver Physiol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4935488/ https://ncbi.nlm.nih.gov/pubmed/26968207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00052.2016 |
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