General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice

Treatment with the antileukemic agent asparaginase can induce acute pancreatitis, but the pathophysiology remains obscure. In the liver of mice, eukaryotic initiation factor 2 (eIF2) kinase general control nonderepressible 2 (GCN2) is essential for mitigating metabolic stress caused by asparaginase....

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Phillipson-Weiner, Lindsey, Mirek, Emily T., Wang, Yongping, McAuliffe, W. Geoffrey, Wek, Ronald C., Anthony, Tracy G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Pancreatic Physiology/Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935488/
https://ncbi.nlm.nih.gov/pubmed/26968207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00052.2016
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