Opioid growth factor and low-dose naltrexone impair central nervous system infiltration by CD4 + T lymphocytes in established experimental autoimmune encephalomyelitis, a model of multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by infiltrating myelin-reactive T lymphocytes and demyelinating lesions. Experimental autoimmune encephalomyelitis (EAE) is the animal model widely utilized to study MS. EAE is mediated by CD4(+) T ce...

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Udgivet i:Exp Biol Med (Maywood)
Main Authors: Hammer, Leslie A, Waldner, Hanspeter, Zagon, Ian S, McLaughlin, Patricia J
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2015
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935426/
https://ncbi.nlm.nih.gov/pubmed/26202376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370215596384
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