Modulation of Sonic hedgehog signaling and WW domain containing oxidoreductase WOX1 expression enhances radiosensitivity of human glioblastoma cells

WW domain containing oxidoreductase, designated WWOX, FOR or WOX1, is a known pro-apoptotic factor when ectopically expressed in various types of cancer cells, including glioblastoma multiforme (GBM). The activation of sonic hedgehog (Shh) signaling, especially paracrine Shh secretion in response to...

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Vydáno v:Exp Biol Med (Maywood)
Hlavní autoři: Chiang, Ming-Fu, Chen, Hsin-Hong, Chi, Chih-Wen, Sze, Chun-I, Hsu, Ming-Ling, Shieh, Hui-Ru, Lin, Chin-Ping, Tsai, Jo-Ting, Chen, Yu-Jen
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935234/
https://ncbi.nlm.nih.gov/pubmed/25595187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370214565989
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