Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease

BACKGROUND: Calcific aortic valve stenosis (AS) is a life-threatening disease with no medical therapy. The genetic architecture of AS remains elusive. This study combines genome-wide association studies, gene expression, and expression quantitative trait loci mapping in human valve tissues to identi...

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Detalhes bibliográficos
Publicado no:Circ Cardiovasc Genet
Main Authors: Guauque-Olarte, Sandra, Messika-Zeitoun, David, Droit, Arnaud, Lamontagne, Maxime, Tremblay-Marchand, Joël, Lavoie-Charland, Emilie, Gaudreault, Nathalie, Arsenault, Benoit J., Dubé, Marie-Pierre, Tardif, Jean-Claude, Body, Simon C., Seidman, Jonathan G., Boileau, Catherine, Mathieu, Patrick, Pibarot, Philippe, Bossé, Yohan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934886/
https://ncbi.nlm.nih.gov/pubmed/26553695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.115.001145
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