Combination of gold nanoparticle-conjugated TNF-α and radiation therapy results in a synergistic anti-tumor response in murine carcinoma models

INTRODUCTION: Although remarkable preclinical antitumor effects have been shown for tumor necrosis factor-α (TNF) alone and in combination with radiation, clinical use is hindered by systemic dose-limiting toxicities. Here, we investigated the physiological and anti-tumor effects of radiotherapy com...

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Udgivet i:Int J Radiat Oncol Biol Phys
Main Authors: Koonce, Nathan A., Quick, Matthew C., Hardee, Matthew E., Jamshidi-Parsian, Azemat, Dent, Judith A., Paciotti, Giulio F., Nedosekin, Dmitry, Dings, Ruud P.M., Griffin, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934370/
https://ncbi.nlm.nih.gov/pubmed/26461001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2015.07.2275
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