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Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction

Reduced mechanistic target of rapamycin (mTOR) signalling extends lifespan in yeast, nematodes, fruit flies and mice, highlighting a physiological pathway that could modulate aging in evolutionarily divergent organisms. This signalling system is also hypothesized to play a central role in lifespan e...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Garratt, Michael, Nakagawa, Shinichi, Simons, Mirre J. P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933670/
https://ncbi.nlm.nih.gov/pubmed/27139919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12489
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