Linking MedDRA®-coded Clinical Phenotypes to Biological Mechanisms by The Ontology of Adverse Events: A pilot study on Tyrosine Kinase Inhibitors (TKIs)

INTRODUCTION: A translational bioinformatics challenge lies in connecting population and individual’s clinical phenotypes in various formats to biological mechanisms. The Medical Dictionary for Regulatory Activities (MedDRA(®)) is the default dictionary for Adverse Event (AE) reporting in the FDA Ad...

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Vydáno v:Drug Saf
Hlavní autoři: Sarntivijai, Sirarat, Zhang, Shelley, Jagannathan, Desikan G., Zaman, Shadia, Burkhart, Keith K., Omenn, Gilbert S., He, Yongqun, Athey, Brian D., Abernethy, Darrell R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933310/
https://ncbi.nlm.nih.gov/pubmed/27003817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40264-016-0414-0
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