Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse

Proper biogenesis of a sperm-specific organelle, the acrosome, is essential for gamete interaction. An acrosomal matrix protein, ACRBP, is known as a proacrosin-binding protein. In mice, two forms of ACRBP, wild-type ACRBP-W and variant ACRBP-V5, are generated by pre-mRNA alternative splicing of Acr...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kanemori, Yoshinori, Koga, Yoshitaka, Sudo, Mai, Kang, Woojin, Kashiwabara, Shin-ichi, Ikawa, Masahito, Hasuwa, Hidetoshi, Nagashima, Kiyoshi, Ishikawa, Yu, Ogonuki, Narumi, Ogura, Atsuo, Baba, Tadashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932935/
https://ncbi.nlm.nih.gov/pubmed/27303034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522333113
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