Diminution of STAT3 signaling inhibits vascular permeability and anaphylaxis

BACKGROUND: During IgE-mediated immediate hypersensitivity reactions, vascular endothelial cells permeabilize in response to mast cell mediators. We have previously demonstrated that patients and mice with STAT3 mutations (autosomal dominant-hyper IgE syndrome; AD-HIES) are partially protected from...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Hox, Valerie, O’Connell, Michael P., Lyons, Jonathan J., Sackstein, Paul, Dimaggio, Thomas, Jones, Nina, Nelson, Celeste, Boehm, Manfred, Holland, Steven M., Freeman, Alexandra F., Tweardy, David J., Olivera, Ana, Metcalfe, Dean D., Milner, Joshua D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931983/
https://ncbi.nlm.nih.gov/pubmed/26948077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.11.024
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