Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD

Maple Syrup Urine Disease (MSUD) is an inherited disorder caused by the dysfunction in the branched chain keto-acid dehydrogenase (BCKDH) enzyme. This leads to buildup of branched-chain keto-acids (BCKA) and branched-chain amino acids (BCAA) in body fluids (e.g. keto-isocaproic acid from the BCAA le...

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Опубликовано в: :Sci Rep
Главные авторы: S. Sonnet, Davis, N. O’Leary, Monique, A. Gutierrez, Mark, M. Nguyen, Steven, Mateen, Samiha, Hsu, Yuehmei, P. Mitchell, Kylie, J. Lopez, Antonio, Vockley, Jerry, K. Kennedy, Brian, Ramanathan, Arvind
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931503/
https://ncbi.nlm.nih.gov/pubmed/27373929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28775
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