Long-read sequencing and de novo assembly of a Chinese genome

Short-read sequencing has enabled the de novo assembly of several individual human genomes, but with inherent limitations in characterizing repeat elements. Here we sequence a Chinese individual HX1 by single-molecule real-time (SMRT) long-read sequencing, construct a physical map by NanoChannel arr...

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Publicat a:Nat Commun
Autors principals: Shi, Lingling, Guo, Yunfei, Dong, Chengliang, Huddleston, John, Yang, Hui, Han, Xiaolu, Fu, Aisi, Li, Quan, Li, Na, Gong, Siyi, Lintner, Katherine E., Ding, Qiong, Wang, Zou, Hu, Jiang, Wang, Depeng, Wang, Feng, Wang, Lin, Lyon, Gholson J., Guan, Yongtao, Shen, Yufeng, Evgrafov, Oleg V., Knowles, James A., Thibaud-Nissen, Francoise, Schneider, Valerie, Yu, Chack-Yung, Zhou, Libing, Eichler, Evan E., So, Kwok-Fai, Wang, Kai
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931320/
https://ncbi.nlm.nih.gov/pubmed/27356984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12065
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