PACAP suppresses dry eye signs by stimulating tear secretion

Dry eye syndrome is caused by a reduction in the volume or quality of tears. Here, we show that pituitary adenylate cyclase-activating polypeptide (PACAP)-null mice develop dry eye-like symptoms such as corneal keratinization and tear reduction. PACAP immunoreactivity is co-localized with a neuronal...

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Published in:Nat Commun
Main Authors: Nakamachi, Tomoya, Ohtaki, Hirokazu, Seki, Tamotsu, Yofu, Sachiko, Kagami, Nobuyuki, Hashimoto, Hitoshi, Shintani, Norihito, Baba, Akemichi, Mark, Laszlo, Lanekoff, Ingela, Kiss, Peter, Farkas, Jozsef, Reglodi, Dora, Shioda, Seiji
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931240/
https://ncbi.nlm.nih.gov/pubmed/27345595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12034
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