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Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide.

The salient pathological feature of Alzheimer disease (AD) is the presence of a high density of amyloid plaques in the brain tissue of victims. The plaques are predominantly composed of human beta-amyloid peptide (beta A4), a 40-mer whose neurotoxicity is related to its aggregation. Radioiodinated h...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Maggio, J E, Stimson, E R, Ghilardi, J R, Allen, C J, Dahl, C E, Whitcomb, D C, Vigna, S R, Vinters, H V, Labenski, M E, Mantyh, P W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49312/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1608956/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.12.5462
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