Processing of miR17-92 Cluster in Hepatic Stellate Cells Promotes Hepatic Fibrogenesis During Alcohol-Induced Injury

BACKGROUND: Exposure to alcohol and its metabolites can initiate hepatic injury and fibrogenesis. Fibrosis is mediated through HSC activation, leading to global changes in mRNA and microRNA (miR) expression. miRs are expressed in cells or shuttled to exosomes which can be detected in tissue culture...

Full description

Saved in:
Bibliographic Details
Published in:Alcohol Clin Exp Res
Main Authors: Brandon-Warner, Elizabeth, Feilen, Nicole, Culberson, Catherine R., Field, Conroy O., deLemos, Andrew S., Russo, Mark W., Schrum, Laura W.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930422/
https://ncbi.nlm.nih.gov/pubmed/27291156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13116
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items