Efficacy, safety, and tolerability of lacosamide in patients with gain-of-function Na(v)1.7 mutation-related small fiber neuropathy: study protocol of a randomized controlled trial–the LENSS study

BACKGROUND: Small fiber neuropathy generally leads to considerable pain and autonomic symptoms. Gain-of-function mutations in the SCN9A- gene, which codes for the Na(v)1.7 voltage-gated sodium channel, have been reported in small fiber neuropathy, suggesting an underlying genetic basis in a subset o...

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Опубликовано в: :Trials
Главные авторы: de Greef, Bianca T. A., Merkies, Ingemar S. J., Geerts, Margot, Faber, Catharina G., Hoeijmakers, Janneke G. J.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2016
Предметы:
Study Protocol
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929773/
https://ncbi.nlm.nih.gov/pubmed/27363506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-016-1430-1
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