Daratumumab: a first-in-class CD38 monoclonal antibody for the treatment of multiple myeloma

Daratumumab is a human monoclonal antibody that targets CD38, a cell surface protein that is overexpressed on multiple myeloma (MM) cells. Preclinical studies have shown that daratumumab induces MM cell death through several mechanisms, including complement-dependent cytotoxicity (CDC), antibody-dep...

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Bibliografiske detaljer
Udgivet i:J Hematol Oncol
Main Authors: Sanchez, Larysa, Wang, Yucai, Siegel, David S., Wang, Michael L.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929758/
https://ncbi.nlm.nih.gov/pubmed/27363983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0283-0
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