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Novel role of cortactin in G protein-coupled receptor agonist-induced nuclear export and degradation of p21Cip1

Monocyte chemotactic protein 1 (MCP1) stimulates phosphorylation of cortactin on Y421 and Y446 residues in a time-dependent manner and phosphorylation at Y446 but not Y421 residue is required for MCP1-induced CDK-interacting protein 1 (p21Cip1) nuclear export and degradation in facilitating human ao...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Janjanam, Jagadeesh, Rao, Gadiparthi N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929470/
https://ncbi.nlm.nih.gov/pubmed/27363897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28687
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