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Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations

Cardiac safety is an issue causing early terminations at various stages of drug development. Efforts are put into the elimination of false negatives as well as false positives resulting from the current testing paradigm. In silico approaches offer mathematical system and data description from the io...

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Vydáno v:Curr Pharmacol Rep
Hlavní autoři: Tylutki, Zofia, Polak, Sebastian, Wiśniowska, Barbara
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929154/
https://ncbi.nlm.nih.gov/pubmed/27429898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40495-016-0060-3
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