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A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression
Multiple human diseases are associated with a liquid-to-solid phase transition resulting in the formation of amyloid fibers or protein aggregates. Here, we present an alternative mechanism for cellular toxicity based on a concentration-dependent liquid-liquid demixing. Analyzing proteins that are to...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cell Press
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4929146/ https://ncbi.nlm.nih.gov/pubmed/27320918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.076 |
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