Partial Protection against Porcine Influenza A Virus by a Hemagglutinin-Expressing Virus Replicon Particle Vaccine in the Absence of Neutralizing Antibodies

This work was initiated by previous reports demonstrating that mismatched influenza A virus (IAV) vaccines can induce enhanced disease, probably mediated by antibodies. Our aim was, therefore, to investigate if a vaccine inducing opsonizing but not neutralizing antibodies against the hemagglutinin (...

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Опубликовано в: :Front Immunol
Главные авторы: Ricklin, Meret E., Vielle, Nathalie J., Python, Sylvie, Brechbühl, Daniel, Zumkehr, Beatrice, Posthaus, Horst, Zimmer, Gert, Summerfield, Artur
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2016
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928594/
https://ncbi.nlm.nih.gov/pubmed/27446083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00253
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