HIF-1alpha Deficiency Attenuates the Cardiomyogenesis of Mouse Embryonic Stem Cells

Cardiac cell formation, cardiomyogenesis, is critically dependent on oxygen availability. It is known that hypoxia, a reduced oxygen level, modulates the in vitro differentiation of pluripotent cells into cardiomyocytes via hypoxia inducible factor-1alpha (HIF-1α)-dependent mechanisms. However, the...

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Udgivet i:PLoS One
Main Authors: Kudová, Jana, Procházková, Jiřina, Vašiček, Ondřej, Perečko, Tomáš, Sedláčková, Miroslava, Pešl, Martin, Pacherník, Jiří, Kubala, Lukáš
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927095/
https://ncbi.nlm.nih.gov/pubmed/27355368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158358
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