The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition

Multiple glycosyltransferases are essential for the proper modification of alpha-dystroglycan, as mutations in the encoding genes cause congenital/limb-girdle muscular dystrophies. Here we elucidate further the structure of an O-mannose-initiated glycan on alpha-dystroglycan that is required to gene...

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Vydáno v:eLife
Hlavní autoři: Praissman, Jeremy L, Willer, Tobias, Sheikh, M Osman, Toi, Ants, Chitayat, David, Lin, Yung-Yao, Lee, Hane, Stalnaker, Stephanie H, Wang, Shuo, Prabhakar, Pradeep Kumar, Nelson, Stanley F, Stemple, Derek L, Moore, Steven A, Moremen, Kelley W, Campbell, Kevin P, Wells, Lance
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Biochemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924997/
https://ncbi.nlm.nih.gov/pubmed/27130732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14473
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