Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans

BACKGROUND: Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, causes extensive tissue destruction by inducing apoptosis of host cells. In this study, we aimed at the production of antibodies that could neutralize the cytotoxic activities of mycolactone. METHODOLOGY/PRINCIPAL FI...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Negl Trop Dis
Auteurs principaux: Dangy, Jean-Pierre, Scherr, Nicole, Gersbach, Philipp, Hug, Melanie N., Bieri, Raphael, Bomio, Claudio, Li, Jun, Huber, Sylwia, Altmann, Karl-Heinz, Pluschke, Gerd
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924874/
https://ncbi.nlm.nih.gov/pubmed/27351976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004808
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