Cardiac myosin-Th17 responses promote heart failure in human myocarditis

In human myocarditis and its sequela dilated cardiomyopathy (DCM), the mechanisms and immune phenotype governing disease and subsequent heart failure are not known. Here, we identified a Th17 cell immunophenotype of human myocarditis/DCM with elevated CD4(+)IL17(+) T cells and Th17-promoting cytokin...

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Publicado en:JCI Insight
Autores principales: Myers, Jennifer M., Cooper, Leslie T., Kem, David C., Stavrakis, Stavros, Kosanke, Stanley D., Shevach, Ethan M., Fairweather, DeLisa, Stoner, Julie A., Cox, Carol J., Cunningham, Madeleine W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924810/
https://ncbi.nlm.nih.gov/pubmed/27366791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85851
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