Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds

Inactivation of the p53 transcription factor by mutation or other mechanisms is a frequent event in tumorigenesis. One of the major endogenous negative regulators of p53 in humans is hDM2, a ubiquitin E3 ligase that binds to p53 causing proteasomal p53 degradation. In this work, a library of organom...

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Udgivet i:Oncotarget
Main Authors: Liu, Li-Juan, He, Bingyong, Miles, Jennifer A., Wang, Wanhe, Mao, Zhifeng, Che, Weng Ian, Lu, Jin-Jian, Chen, Xiu-Ping, Wilson, Andrew J., Ma, Dik-Lung, Leung, Chung-Hang
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924691/
https://ncbi.nlm.nih.gov/pubmed/26883110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7369
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