Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification

BACKGROUND: Spatial heterogeneity in biomarker expression may impact breast cancer classification. The aims of this study were to estimate the frequency of spatial heterogeneity in biomarker expression within tumors, to identify technical and biological factors contributing to spatial heterogeneity,...

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Veröffentlicht in:Breast Cancer Res
Hauptverfasser: Allott, Emma H., Geradts, Joseph, Sun, Xuezheng, Cohen, Stephanie M., Zirpoli, Gary R., Khoury, Thaer, Bshara, Wiam, Chen, Mengjie, Sherman, Mark E., Palmer, Julie R., Ambrosone, Christine B., Olshan, Andrew F., Troester, Melissa A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924300/
https://ncbi.nlm.nih.gov/pubmed/27349894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-016-0725-1
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