Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification

BACKGROUND: Spatial heterogeneity in biomarker expression may impact breast cancer classification. The aims of this study were to estimate the frequency of spatial heterogeneity in biomarker expression within tumors, to identify technical and biological factors contributing to spatial heterogeneity,...

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Vydáno v:Breast Cancer Res
Hlavní autoři: Allott, Emma H., Geradts, Joseph, Sun, Xuezheng, Cohen, Stephanie M., Zirpoli, Gary R., Khoury, Thaer, Bshara, Wiam, Chen, Mengjie, Sherman, Mark E., Palmer, Julie R., Ambrosone, Christine B., Olshan, Andrew F., Troester, Melissa A.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924300/
https://ncbi.nlm.nih.gov/pubmed/27349894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-016-0725-1
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