Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats

BACKGROUND: Hyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall. However, the role of HHcy in the growth and rupture of cerebral aneurysms remains unclear. METHODS: Thirteen-week-old female Sprague-Dawley...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Korai, Masaaki, Kitazato, Keiko T., Tada, Yoshiteru, Miyamoto, Takeshi, Shimada, Kenji, Matsushita, Nobuhisa, Kanematsu, Yasuhisa, Satomi, Junichiro, Hashimoto, Tomoki, Nagahiro, Shinji
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924228/
https://ncbi.nlm.nih.gov/pubmed/27349749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0634-3
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