In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity

Glycolysis, as an altered cancer cell-intrinsic metabolism, is an essential hallmark of cancer. Phosphofructokinase (PFK) is a metabolic sensor in the glycolytic pathway, and restricting the substrate availability for this enzyme has been researched extensively as a target for chemotherapy. In the p...

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Udgivet i:Sci Rep
Main Authors: Li, Sainan, Wu, Liwei, Feng, Jiao, Li, Jingjing, Liu, Tong, Zhang, Rong, Xu, Shizan, Cheng, Keran, Zhou, Yuqing, Zhou, Shunfeng, Kong, Rui, Chen, Kan, Wang, Fan, Xia, Yujing, Lu, Jie, Zhou, Yingqun, Dai, Weiqi, Guo, Chuanyong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923908/
https://ncbi.nlm.nih.gov/pubmed/27349173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28479
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