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Epigenetic repression of ribosomal RNA transcription by ROCK-dependent aberrant cytoskeletal organization

It is known that ribosomal RNA (rRNA) synthesis is regulated by cellular energy and proliferation status. In this study, we investigated rRNA gene transcription in response to cytoskeletal stress. Our data revealed that the cell shape constrained by isotropic but not elongated micropatterns in HeLa...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wu, Tse-Hsiang, Kuo, Yuan-Yeh, Lee, Hsiao-Hui, Kuo, Jean-Cheng, Ou, Meng-Hsin, Chang, Zee-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923894/
https://ncbi.nlm.nih.gov/pubmed/27350000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28685
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