Spontaneous mutations in Streptococcus pyogenes isolates from streptococcal toxic shock syndrome patients play roles in virulence

Streptococcus pyogenes (group A Streptococcus; GAS) is a widespread human pathogen and causes streptococcal toxic shock syndrome (STSS). STSS isolates have been previously shown to have high frequency mutations in the csrS/csrR (covS/covR) and/or rgg (ropB) genes, which are negative regulators of vi...

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Published in:Sci Rep
Main Authors: Ikebe, Tadayoshi, Matsumura, Takayuki, Nihonmatsu, Hisako, Ohya, Hitomi, Okuno, Rumi, Mitsui, Chieko, Kawahara, Ryuji, Kameyama, Mitsuhiro, Sasaki, Mari, Shimada, Naomi, Ato, Manabu, Ohnishi, Makoto
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923885/
https://ncbi.nlm.nih.gov/pubmed/27349341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28761
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