Randomized Phase 2 Trial of the Oncolytic Virus Pelareorep (Reolysin) in Upfront Treatment of Metastatic Pancreatic Adenocarcinoma

Pelareorep causes oncolysis in tumor cells with activated Ras. We hypothesized that pelareorep would have efficacy and immunomodulatory activity in metastatic pancreatic adenocarcinoma (MPA) when combined with carboplatin and paclitaxel. A randomized phase 2 study (NCT01280058) was conducted in trea...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Noonan, Anne M, Farren, Matthew R, Geyer, Susan M, Huang, Ying, Tahiri, Sanaa, Ahn, Daniel, Mikhail, Sameh, Ciombor, Kristen K, Pant, Shubham, Aparo, Santiago, Sexton, Jennifer, Marshall, John L, Mace, Thomas A, Wu, Christina S, El-Rayes, Bassel, Timmers, Cynthia D, Zwiebel, James, Lesinski, Gregory B, Villalona-Calero, Miguel A, Bekaii-Saab, Tanios S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923331/
https://ncbi.nlm.nih.gov/pubmed/27039845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.66
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