Targeting the cAMP and Transforming Growth Factor-β Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium

Retinal pigment epithelium (RPE) cell integrity is critical to the maintenance of retinal function. Many retinopathies such as age-related macular degeneration (AMD) are caused by the degeneration or malfunction of the RPE cell layer. Replacement of diseased RPE with healthy, stem cell-derived RPE i...

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Veröffentlicht in:Stem Cells Transl Med
Hauptverfasser: Choudhary, Parul, Gutteridge, Alex, Impey, Emma, Storer, R. Ian, Owen, Robert M., Whiting, Paul J., Bictash, Magda, Benn, Caroline L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AlphaMed Press 2016
Schlagworte:
Enabling Technologies for Cell-Based Clinical Translation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922849/
https://ncbi.nlm.nih.gov/pubmed/27112176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0247
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