Increased mitochondrial arginine metabolism supports bioenergetics in asthma

High levels of arginine metabolizing enzymes, including inducible nitric oxide synthase (iNOS) and arginase (ARG), are typical in asthmatic airway epithelium; however, little is known about the metabolic effects of enhanced arginine flux in asthma. Here, we demonstrated that increased metabolism sus...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Principais autores: Xu, Weiling, Ghosh, Sudakshina, Comhair, Suzy A.A., Asosingh, Kewal, Janocha, Allison J., Mavrakis, Deloris A., Bennett, Carole D., Gruca, Lourdes L., Graham, Brian B., Queisser, Kimberly A., Kao, Christina C., Wedes, Samuel H., Petrich, John M., Tuder, Rubin M., Kalhan, Satish C., Erzurum, Serpil C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922712/
https://ncbi.nlm.nih.gov/pubmed/27214549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82925
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