Increased mitochondrial arginine metabolism supports bioenergetics in asthma

High levels of arginine metabolizing enzymes, including inducible nitric oxide synthase (iNOS) and arginase (ARG), are typical in asthmatic airway epithelium; however, little is known about the metabolic effects of enhanced arginine flux in asthma. Here, we demonstrated that increased metabolism sus...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Xu, Weiling, Ghosh, Sudakshina, Comhair, Suzy A.A., Asosingh, Kewal, Janocha, Allison J., Mavrakis, Deloris A., Bennett, Carole D., Gruca, Lourdes L., Graham, Brian B., Queisser, Kimberly A., Kao, Christina C., Wedes, Samuel H., Petrich, John M., Tuder, Rubin M., Kalhan, Satish C., Erzurum, Serpil C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922712/
https://ncbi.nlm.nih.gov/pubmed/27214549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82925
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