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Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction

Extended synaptotagmins (ESyts) are endoplasmic reticulum (ER) proteins composed of an N-terminal transmembrane region, a central SMP-domain, and five (ESyt1) or three C-terminal cytoplasmic C2-domains (ESyt2 and ESyt3). ESyts bind phospholipids in a Ca(2+)-dependent manner via their C2-domains, are...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Sclip, Alessandra, Bacaj, Taulant, Giam, Louise R., Südhof, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922586/
https://ncbi.nlm.nih.gov/pubmed/27348751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158295
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