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Non-Markovian effects on protein sequence evolution due to site dependent substitution rates

BACKGROUND: Many models of protein sequence evolution, in particular those based on Point Accepted Mutation (PAM) matrices, assume that its dynamics is Markovian. Nevertheless, it has been observed that evolution seems to proceed differently at different time scales, questioning this assumption. In...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Rizzato, Francesca, Rodriguez, Alex, Laio, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4921000/
https://ncbi.nlm.nih.gov/pubmed/27342318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-016-1135-1
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