Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment

BACKGROUND: Aberrant patterns of DNA methylation are abundant in cancer, and epigenetic pathways are increasingly being targeted in cancer drug treatment. Genetic components of the folate-mediated one-carbon metabolism pathway can affect DNA methylation and other vital cell functions, including DNA...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Krushkal, Julia, Zhao, Yingdong, Hose, Curtis, Monks, Anne, Doroshow, James H., Simon, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919895/
https://ncbi.nlm.nih.gov/pubmed/27347216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0240-3
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