Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants

Although both C-C chemokine receptor 5 (CCR5)- and CXC chemokine receptor 4 (CXCR4)-using HIV-1 strains cause AIDS, the emergence of CXCR4-utilizing variants is associated with an accelerated decline in CD4 + T cells. It remains uncertain if CXCR4-using viruses hasten disease or if these variants on...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Lin, Nina, Gonzalez, Oscar A., Registre, Ludy, Becerril, Carlos, Etemad, Behzad, Lu, Hong, Wu, Xueling, Lockman, Shahin, Essex, Myron, Moyo, Sikhulile, Kuritzkes, Daniel R., Sagar, Manish
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919596/
https://ncbi.nlm.nih.gov/pubmed/27428434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.04.040
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