Supplementation of host response by targeting nitric oxide to the macrophage cytosol is efficacious in the hamster model of visceral leishmaniasis and adds to efficacy of amphotericin B

We investigated efficacy of nitric oxide (NO) against Leishmania donovani. NO is a mediator of host response to infection, with direct parasiticidal activity in addition to its role in signalling to evoke innate macrophage responses. However, it is short-lived and volatile, and is therefore difficul...

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Bibliografiske detaljer
Udgivet i:	Int J Parasitol Drugs Drug Resist
Main Authors:	Pandya, Sanketkumar, Verma, Rahul Kumar, Khare, Prashant, Tiwari, Brajendra, Srinivasarao, Dadi A., Dube, Anuradha, Goyal, Neena, Misra, Amit
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2016
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4919251/ https://ncbi.nlm.nih.gov/pubmed/27183429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2016.01.001
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Supplementation of host response by targeting nitric oxide to the macrophage cytosol is efficacious in the hamster model of visceral leishmaniasis and adds to efficacy of amphotericin B

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