Reactivation of Endogenous Genes and Epigenetic Remodeling Are Barriers for Generating Transgene-Free Induced Pluripotent Stem Cells in Pig

Cellular reprogramming of committed cells into a pluripotent state can be induced by ectopic expression of genes such as OCT4, SOX2, KLF4, and MYC. Reprogrammed cells can be maintained by activating endogenous pluripotent networks without transgene expression. Although various research groups have a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Choi, Kwang-Hwan, Park, Jin-Kyu, Son, Dongchan, Hwang, Jae Yeon, Lee, Dong-Kyung, Ka, Hakhyun, Park, Joonghoon, Lee, Chang-Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918974/
https://ncbi.nlm.nih.gov/pubmed/27336671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158046
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